The royal figure gives up his title as the Duke.
He is surrendering his titles, including the Duke of York, he has declared in a own words.
He has been under mounting attention over his links with disgraced financier the financier, with calls for the royal household to take action against him.
That now appears to have resulted in the figure deciding to voluntarily give up his designations and to relinquish involvement of the prestigious order.
In his statement he said he continued to "firmly dispute the accusations against me".
"In talks with the King, and my immediate and wider family, we have agreed the ongoing accusations about me distract from the work of the monarch and the Royal Family," said a statement from the royal.
"I have chosen, as I always have, to put my obligation to my kin and nation first.
"I support my resolution five years ago to step back from royal engagements.
"With His Majesty's consent, we feel I must now go a further step. I will therefore no longer hold my designation or the awards which have been conferred upon me. As I have said previously, I firmly refute the accusations against me."
He has encountered a range of controversies, including a lawsuit he ended with Virginia Giuffre, doubts about his economic affairs and his involvement with an accused intelligence operative.
He will stay a royal - but will cease to be the Duke of York, a title granted from his mother, the late Queen Elizabeth.
He had already stopped to be a "working royal" and had forfeited the use of his royal style and no longer participated at official royal events. His status now will be even more lessened.
His previous partner will be known as Sarah Ferguson and no longer York's Duchess, but their daughters will carry on to have the honor of princess.
He has encountered severe attention over his associations with convicted sex offender the financier, more lately involving inquiries about when he had actually severed contact.
In his television appearance, Prince Andrew had said that he had ended all ties with Jeffrey Epstein after they had been photographed together in NYC in December 2010.
But messages sent in February 2011 later surfaced indicating that he had confidentially continued in communication with Epstein, for example swapping a message: "Remain connected and we'll have further interactions soon!"
There had been growing displeasure in the monarchy at the scandals that remained to envelop the figure.
In the coming days a book released after death by the accuser will be issued which is expected to draw additional attention on the royal's connection with Virginia Giuffre and Jeffrey Epstein.
